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When vigilante David Dunn (Bruce Willis) confronts the split personality killer named “The Beast” (James McAvoy), their showdown is interrupted by the authorities.

Captured, both men are sent to Raven Hill Memorial Psychiatric Hospital for evaluation by Dr. Ellie Staple (Sarah Paulson).

Dunn soon discovers that his nemesis, Elijah Price (Samuel L. Jackson) is also incarcerated here.

Dr. Staple is convinced that these men suffer delusions of grandeur in thinking they are superheroes. She is certain that these men are influenced by comics – does life imitate art or does art imitate life?